IKBKG

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY

Identifiers

Aliases

IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, inhibitor of nuclear factor kappa B kinase subunit gamma

External IDs

OMIM: 300248 MGI: 1338074 HomoloGene: 2698 GeneCards: IKBKG

Gene ontology
Molecular function	• protein homodimerization activity • protein domain specific binding • signal transducer activity • metal ion binding • K63-linked polyubiquitin binding • protein binding • peroxisome proliferator activated receptor binding • linear polyubiquitin binding • protein heterodimerization activity • ubiquitin protein ligase binding • polyubiquitin binding
Cellular component	• cytoplasm • spindle pole • ubiquitin ligase complex • intracellular • IkappaB kinase complex • mitotic spindle • nucleus • cytosol
Biological process	• regulation of transcription, DNA-templated • regulation of tumor necrosis factor-mediated signaling pathway • response to virus • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • JNK cascade • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • stress-activated MAPK cascade • immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • inflammatory response • viral process • I-kappaB kinase/NF-kappaB signaling • T cell receptor signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • establishment of vesicle localization • positive regulation of transcription from RNA polymerase II promoter • negative regulation of neuron death • apoptotic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • cellular response to DNA damage stimulus • positive regulation of macroautophagy • protein deubiquitination • anoikis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8517


16151

Ensembl


ENSG00000269335


ENSMUSG00000004221

UniProt


Q9Y6K9


O88522

RefSeq (mRNA)

NM_001099856 NM_001099857 NM_001145255 NM_003639 NM_001321396
NM_001321397

NM_001136067 NM_001161421 NM_001161422 NM_001161423 NM_001161424
NM_010547 NM_178590

RefSeq (protein)

NP_001093326 NP_001093327 NP_001138727 NP_001308325 NP_001308326
NP_003630

NP_001154895.1 NP_034677.2 NP_001129539 NP_001154893 NP_001154894
NP_001154895 NP_001154896 NP_034677 NP_848705

Location (UCSC)

Chr X: 154.54 – 154.57 Mb

Chr X: 74.39 – 74.45 Mb

PubMed search

2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY

NP_001154895
NP_001154896
NP_034677
NP_848705

...
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