IGFBP4

IGFBP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WQJ, 2DSP, 2DSQ, 2DSR
Identifiers
Aliases	IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4, insulin like growth factor binding protein 4
External IDs	MGI: 96439 HomoloGene: 1192 GeneCards: IGFBP4
Gene ontology Molecular function • insulin-like growth factor I binding • insulin-like growth factor II binding • receptor binding • insulin-like growth factor binding • growth factor binding Cellular component • extracellular region • extracellular space Biological process • cellular protein metabolic process • skeletal system development • regulation of growth • DNA metabolic process • regulation of insulin-like growth factor receptor signaling pathway • regulation of glucose metabolic process • cell proliferation • inflammatory response • positive regulation of insulin-like growth factor receptor signaling pathway • type B pancreatic cell proliferation • negative regulation of canonical Wnt signaling pathway • regulation of cell growth • signal transduction • positive regulation of MAPK cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3487	16010
Ensembl	ENSG00000141753	ENSMUSG00000017493
UniProt	P22692	P47879
RefSeq (mRNA)	NM_001552	NM_010517
RefSeq (protein)	NP_001543	NP_034647.1 NP_034647
Location (UCSC)	Chr 17: 40.44 – 40.46 Mb	Chr 11: 99.04 – 99.05 Mb
PubMed search

1WQJ, 2DSP, 2DSQ, 2DSR

3487

16010

ENSG00000141753

ENSMUSG00000017493

P22692

P47879

NM_001552

NM_010517

NP_001543

NP_034647.1
NP_034647

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.

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Wikipedia