IGF2BP3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E44

Identifiers

Aliases

IGF2BP3, CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin like growth factor 2 mRNA binding protein 3

External IDs

MGI: 1890359 HomoloGene: 4773 GeneCards: IGF2BP3

Gene ontology
Molecular function	• mRNA 5'-UTR binding • protein binding • translation regulator activity • mRNA 3'-UTR binding • nucleic acid binding • RNA binding
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• regulation of cytokine biosynthetic process • anatomical structure morphogenesis • negative regulation of translation • mRNA transport • translation • regulation of translation • regulation of mRNA stability • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10643


140488

Ensembl


ENSG00000136231


ENSMUSG00000029814

UniProt


O00425


Q9CPN8

RefSeq (mRNA)


NM_006547


NM_023670

RefSeq (protein)


NP_006538


NP_076159

Location (UCSC)

Chr 7: 23.31 – 23.47 Mb

Chr 6: 49.09 – 49.21 Mb

PubMed search

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

...
Wikipedia