IGF2BP2

IGF2BP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQH
Identifiers
Aliases	IGF2BP2, IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDs	MGI: 1890358 HomoloGene: 4774 GeneCards: IGF2BP2
Genetically Related Diseases
type 2 diabetes mellitus, gestational diabetes
Gene ontology Molecular function • mRNA 5'-UTR binding • protein binding • mRNA binding • translation regulator activity • mRNA 3'-UTR binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • cytoskeleton • nucleus • cytosol Biological process • transport • regulation of cytokine biosynthetic process • anatomical structure morphogenesis • negative regulation of translation • mRNA transport • gene expression • regulation of translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10644	319765
Ensembl	ENSG00000073792	ENSMUSG00000033581
UniProt	Q9Y6M1	Q5SF07
RefSeq (mRNA)	NM_001007225 NM_001291869 NM_001291872 NM_001291873 NM_001291874 NM_001291875 NM_006548	NM_183029
RefSeq (protein)	NP_001007226 NP_001278798 NP_001278801 NP_001278802 NP_001278803 NP_001278804 NP_006539	NP_898850.2 NP_898850
Location (UCSC)	Chr 3: 185.64 – 185.83 Mb	Chr 16: 22.06 – 22.16 Mb
PubMed search

2CQH

10644

319765

ENSG00000073792

ENSMUSG00000033581

Q9Y6M1

Q5SF07

NM_001291875
NM_006548

NM_183029

NP_001278804
NP_006539

NP_898850.2
NP_898850

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Wikipedia