IGF2BP1

IGF2BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KRM
Identifiers
Aliases	IGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDs	MGI: 1890357 HomoloGene: 4772 GeneCards: IGF2BP1
Gene ontology Molecular function • translation regulator activity • mRNA 3'-UTR binding • protein binding • nucleic acid binding • mRNA 5'-UTR binding • mRNA binding • RNA binding Cellular component • cytoplasm • CRD-mediated mRNA stability complex • cell projection • filopodium • growth cone • dendritic spine • intracellular ribonucleoprotein complex • axon • dendrite • perinuclear region of cytoplasm • cytoplasmic stress granule • nucleus • lamellipodium • nucleoplasm • cytosol Biological process • CRD-mediated mRNA stabilization • mRNA transport • negative regulation of translation • gene expression • pallium cell proliferation in forebrain • neuronal stem cell population maintenance • transport • regulation of cytokine biosynthetic process • RNA localization • regulation of translation • regulation of mRNA stability involved in response to stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10642	140486
Ensembl	ENSG00000159217	ENSMUSG00000013415
UniProt	Q9NZI8	O88477
RefSeq (mRNA)	NM_001160423 NM_006546	NM_009951
RefSeq (protein)	NP_001153895 NP_006537	NP_034081.1 NP_034081
Location (UCSC)	Chr 17: 49 – 49.06 Mb	Chr 11: 95.96 – 96.01 Mb
PubMed search

3KRM

10642

140486

ENSG00000159217

ENSMUSG00000013415

Q9NZI8

O88477

NM_001160423
NM_006546

NM_009951

NP_001153895
NP_006537

NP_034081.1
NP_034081

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

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