IGF-I

IGF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Identifiers
Aliases	IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1
External IDs	OMIM: 147440 MGI: 96432 HomoloGene: 515 GeneCards: IGF1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.2 Start 102,395,867 bp End 102,480,645 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C1|10 43.7 cM Start 87,858,265 bp End 87,937,042 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity • insulin receptor binding • growth factor activity • integrin binding • protein binding • insulin-like growth factor receptor binding Cellular component • extracellular region • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • plasma membrane • extracellular space Biological process • positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • movement of cell or subcellular component • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • DNA replication • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • cell proliferation • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of protein import into nucleus, translocation • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • regulation of gene expression • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • cellular protein metabolic process • muscle hypertrophy • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell growth involved in cardiac muscle cell development • activation of MAPK activity • positive regulation of cell proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3479	16000
Ensembl	ENSG00000017427	ENSMUSG00000020053
UniProt	P05019	P05017
RefSeq (mRNA)	NM_000618 NM_001111283 NM_001111284 NM_001111285	NM_001111274 NM_001111275 NM_001111276 NM_010512 NM_184052 NM_001314010
RefSeq (protein)	NP_000609 NP_001104753 NP_001104754 NP_001104755	NP_001104744 NP_001104745 NP_001104746 NP_001300939 NP_034642
Location (UCSC)	Chr 12: 102.4 – 102.48 Mb	Chr 12: 87.86 – 87.94 Mb
PubMed search

1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS

3479

16000

ENSG00000017427

ENSMUSG00000020053

P05019

P05017

NM_000618
NM_001111283
NM_001111284
NM_001111285

...
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