IFNAR1

IFNAR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S98, 3SE3, 3SE4, 4PO6
Identifiers
Aliases	IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, interferon alpha and beta receptor subunit 1
External IDs	MGI: 107658 HomoloGene: 524 GeneCards: IFNAR1
Gene ontology Molecular function • interferon receptor activity • type I interferon receptor activity • protein binding • type I interferon binding • interleukin-10 receptor activity Cellular component • integral component of membrane • endosome • late endosome • membrane • plasma membrane • integral component of plasma membrane • lysosome Biological process • JAK-STAT cascade • response to virus • positive regulation of interferon-gamma production • positive regulation of transcription, DNA-templated • response to lipopolysaccharide • regulation of type I interferon-mediated signaling pathway • defense response to virus • type I interferon signaling pathway • positive regulation of interleukin-1 beta secretion • cellular response to interferon-alpha • type I interferon biosynthetic process • T cell activation • regulation of peptidyl-tyrosine phosphorylation • positive regulation of interferon-beta production • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3454	15975
Ensembl	ENSG00000142166	ENSMUSG00000022967
UniProt	P17181	P33896
RefSeq (mRNA)	NM_000629	NM_010508
RefSeq (protein)	NP_000620	NP_034638.2 NP_034638
Location (UCSC)	Chr 21: 33.32 – 33.36 Mb	Chr 16: 91.49 – 91.51 Mb
PubMed search

3S98, 3SE3, 3SE4, 4PO6

3454

15975

ENSG00000142166

ENSMUSG00000022967

P17181

P33896

NM_000629

NM_010508

NP_000620

NP_034638.2
NP_034638

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

IFNAR1 has been shown to interact with:

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Wikipedia