IFNA2

IFNA2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1RH2, 3S9D, 1ITF, 2LAG, 4YPG, 2KZ1, 2HYM, 2LMS, 3SE3, 4Z5R
Identifiers
Aliases	IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2, interferon, alpha 2, interferon alpha 2
External IDs	HomoloGene: 86655 GeneCards: IFNA2
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding • protein binding • cytokine receptor binding Cellular component • extracellular region • extracellular space Biological process • apoptotic process • defense response • negative regulation of interleukin-5 secretion • negative regulation of viral entry into host cell • negative regulation of interleukin-13 secretion • response to exogenous dsRNA • cell-cell signaling • negative regulation of T-helper 2 cell cytokine production • blood coagulation • positive regulation of peptidyl-serine phosphorylation of STAT protein • positive regulation of tyrosine phosphorylation of Stat3 protein • negative regulation of gene expression • positive regulation of transcription, DNA-templated • natural killer cell activation involved in immune response • cell surface receptor signaling pathway • B cell proliferation • regulation of type I interferon-mediated signaling pathway • humoral immune response • type I interferon signaling pathway • B cell differentiation • positive regulation of phosphorylation • inflammatory response • negative regulation of transcription, DNA-templated • negative regulation of T cell differentiation • T cell activation involved in immune response • defense response to virus • innate immune response • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3440	n/a
Ensembl	ENSG00000188379	n/a
UniProt	P01563	n/a
RefSeq (mRNA)	NM_000605	n/a
RefSeq (protein)	NP_000596	n/a
Location (UCSC)	Chr 9: 21.38 – 21.39 Mb	n/a
PubMed search		n/a

1RH2, 3S9D, 1ITF, 2LAG, 4YPG, 2KZ1, 2HYM, 2LMS, 3SE3, 4Z5R

3440

n/a

ENSG00000188379

n/a

P01563

n/a

NM_000605

n/a

NP_000596

n/a

Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene.

Human interferon alpha-2 (IFNα2) is a cytokine belonging to the family of type I IFNs. IFNα2 is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. The first description of IFNs as a cellular agent interfering with viral replication was made by Alick Isaacs and Jean Lindenmann in 1957. The history of this finding was recently reviewed. There are 3 types of IFNs: Interferon type I, Interferon type II and Interferon type III. The type II IFN, also called IFNγ, is produced by specific cells of the immune system. Unlike type I and type III IFNs, IFNγ has only a modest role in directly restricting viral infections. Type I and type III IFNs act similarly. However, the action of type III IFNs, also known as IFNλ, is limited to epithelial cells while type I IFNs act on all body's cells.

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Wikipedia