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IFN-γ

IFNG
IFN.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IFNG, IFG, IFI, interferon, gamma, interferon gamma
External IDs MGI: 107656 HomoloGene: 55526 GeneCards: IFNG
RNA expression pattern
PBB GE IFNG 210354 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000619

NM_008337

RefSeq (protein)

NP_000610

NP_032363.1
NP_032363

Location (UCSC) Chr 12: 68.15 – 68.16 Mb Chr 10: 118.44 – 118.45 Mb
PubMed search
Interferon gamma
PDB 1eku EBI.jpg
Crystal structure of a biologically active single chain mutant of human interferon gamma
Identifiers
Symbol IFN gamma
Pfam PF00714
Pfam clan CL0053
InterPro IPR002069
SCOP 1rfb
SUPERFAMILY 1rfb
Interferon gamma
Clinical data
Trade names Actimmune
AHFS/Drugs.com Monograph
MedlinePlus a601152
ATC code L03AB03 (WHO)
Identifiers
CAS Number 98059-61-1 YesY
DrugBank DB00033 N
ChemSpider none
UNII 21K6M2I7AG YesY
ChEMBL CHEMBL1201564 N
Chemical and physical data
Formula C761H1206N214O225S6
Molar mass 17145.6 g/mol
 NYesY (what is this?)  

1EKU, 1FG9, 1FYH, 1HIG, 3BES

NM_000619

NM_008337

NP_000610

NP_032363.1
NP_032363

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.


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