ICAM-1

ICAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
Identifiers
Aliases	ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1
External IDs	OMIM: 147840 MGI: 96392 HomoloGene: 168 GeneCards: ICAM1
Gene ontology Molecular function • virus receptor activity • protein complex binding • integrin binding • protein binding • transmembrane signaling receptor activity • receptor activity Cellular component • integral component of membrane • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • cell surface • immunological synapse • membrane raft • extracellular exosome • external side of plasma membrane • extracellular space Biological process • leukocyte cell-cell adhesion • response to ionizing radiation • establishment of endothelial barrier • negative regulation of endothelial cell apoptotic process • single organismal cell-cell adhesion • cellular response to organic substance • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • response to amino acid • response to hypoxia • positive regulation of actin filament polymerization • response to organic cyclic compound • T cell antigen processing and presentation • establishment of Sertoli cell barrier • response to sulfur dioxide • response to copper ion • interferon-gamma-mediated signaling pathway • positive regulation of nitric oxide biosynthetic process • response to amphetamine • cellular response to tumor necrosis factor • regulation of leukocyte mediated cytotoxicity • T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • extracellular matrix organization • acute inflammatory response to antigenic stimulus • sensory perception of sound • cellular response to alkaloid • response to gonadotropin • positive regulation of cellular extravasation • receptor-mediated virion attachment to host cell • cell aging • positive regulation of GTPase activity • response to lipopolysaccharide • regulation of cell adhesion • cell adhesion • cell adhesion mediated by integrin • positive regulation of NF-kappaB transcription factor activity • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of vasoconstriction • cellular response to interleukin-1 • cellular response to nutrient levels • negative regulation of calcium ion transport • regulation of cell shape • membrane to membrane docking • positive regulation of peptidyl-tyrosine phosphorylation • ovarian follicle development • regulation of immune response • positive regulation of ERK1 and ERK2 cascade • regulation of ruffle assembly • viral entry into host cell • adhesion of symbiont to host • response to ethanol • viral process • cellular response to lipopolysaccharide • cellular response to hypoxia • response to drug • leukocyte migration • cellular response to glucose stimulus • response to insulin • cellular response to interferon-gamma • cellular response to interleukin-6 • cellular response to dexamethasone stimulus • establishment of endothelial intestinal barrier • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3383	15894
Ensembl	ENSG00000090339	ENSMUSG00000037405
UniProt	P05362	P13597
RefSeq (mRNA)	NM_000201	NM_010493
RefSeq (protein)	NP_000192	NP_034623.1 NP_034623
Location (UCSC)	Chr 19: 10.27 – 10.29 Mb	Chr 9: 21.02 – 21.03 Mb
PubMed search

1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX

3383

15894

ENSG00000090339

ENSMUSG00000037405

P05362

P13597

NM_000201

NM_010493

NP_000192

NP_034623.1
NP_034623

ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor.

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