IκBα

NFKBIA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IKN, 1NFI
Identifiers
Aliases	NFKBIA, IKBA, MAD-3, NFKBI, NFKB inhibitor alpha
External IDs	OMIM: 164008 MGI: 104741 HomoloGene: 7863 GeneCards: NFKBIA
Gene ontology Molecular function • heat shock protein binding • protein complex binding • transcription factor binding • NF-kappaB binding • protein binding • nuclear localization sequence binding • identical protein binding • enzyme binding • ubiquitin protein ligase binding Cellular component • cytoplasm • I-kappaB/NF-kappaB complex • plasma membrane • protein complex • nucleus • cytosol Biological process • response to muscle stretch • positive regulation of cellular protein metabolic process • response to exogenous dsRNA • cytoplasmic sequestering of transcription factor • negative regulation of DNA binding • protein import into nucleus, translocation • cellular response to organic cyclic compound • cytoplasmic sequestering of NF-kappaB • stimulatory C-type lectin receptor signaling pathway • response to muramyl dipeptide • negative regulation of apoptotic process • cellular response to cytokine stimulus • Fc-epsilon receptor signaling pathway • positive regulation of transcription, DNA-templated • response to lipopolysaccharide • cellular response to cold • regulation of cell proliferation • positive regulation of cholesterol efflux • positive regulation of NF-kappaB transcription factor activity • nucleotide-binding oligomerization domain containing 2 signaling pathway • regulation of gene expression • negative regulation of lipid storage • regulation of NF-kappaB import into nucleus • viral process • negative regulation of NF-kappaB transcription factor activity • negative regulation of myeloid cell differentiation • T cell receptor signaling pathway • negative regulation of macrophage derived foam cell differentiation • nucleotide-binding oligomerization domain containing 1 signaling pathway • lipopolysaccharide-mediated signaling pathway • negative regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • liver regeneration • toll-like receptor 4 signaling pathway • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4792	18035
Ensembl	ENSG00000100906	ENSMUSG00000021025
UniProt	P25963	Q9Z1E3
RefSeq (mRNA)	NM_020529	NM_010907
RefSeq (protein)	NP_065390	NP_035037.2 NP_035037
Location (UCSC)	Chr 14: 35.4 – 35.4 Mb	Chr 12: 55.49 – 55.49 Mb
PubMed search

1IKN, 1NFI

4792

18035

ENSG00000100906

ENSMUSG00000021025

P25963

Q9Z1E3

NM_020529

NM_010907

NP_065390

NP_035037.2
NP_035037

IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

The gene encoding the IκBα protein is mutated in some Hodgkin's lymphoma cells; such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.

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Wikipedia