Hypoxanthine guanine phosphoribosyl transferase

HPRT1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BZY, 1D6N, 1HMP, 1Z7G, 3GEP, 3GGC, 3GGJ, 2VFA, 4IJQ, 4KN6, 4RAB, 4RAC, 4RAD, 4RAN, 4RAO, 4RAQ, 5BSK, 5BRN

Identifiers

Aliases

HPRT1, HGPRT, HPRT, hypoxanthine phosphoribosyltransferase 1

External IDs

OMIM: 308000 MGI: 96217 HomoloGene: 56590 GeneCards: HPRT1

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein homodimerization activity • transferase activity, transferring glycosyl groups • hypoxanthine phosphoribosyltransferase activity • guanine phosphoribosyltransferase activity • metal ion binding • protein binding • magnesium ion binding • identical protein binding
Cellular component	• cytoplasm • extracellular exosome • cytosol
Biological process	• purine nucleotide biosynthetic process • grooming behavior • cytolysis • purine ribonucleoside salvage • GMP catabolic process • locomotory behavior • dendrite morphogenesis • hypoxanthine metabolic process • guanine salvage • response to amphetamine • purine-containing compound salvage • nucleoside metabolic process • dopamine metabolic process • central nervous system neuron development • lymphocyte proliferation • cerebral cortex neuron differentiation • IMP metabolic process • protein homotetramerization • striatum development • hypoxanthine salvage • adenine metabolic process • positive regulation of dopamine metabolic process • adenine salvage • IMP salvage
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3251


15452

Ensembl


ENSG00000165704


ENSMUSG00000025630

UniProt


P00492


P00493

RefSeq (mRNA)


NM_000194


NM_013556

RefSeq (protein)


NP_000185


NP_038584.2 NP_038584

Location (UCSC)

Chr X: 134.46 – 134.52 Mb

Chr X: 52.99 – 53.02 Mb

PubMed search

hypoxanthine phosphoribosyltransferase

Identifiers

Databases

PDB structures

AmiGO / EGO

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PMC	articles
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NCBI	proteins

1BZY, 1D6N, 1HMP, 1Z7G, 3GEP, 3GGC, 3GGJ, 2VFA, 4IJQ, 4KN6, 4RAB, 4RAC, 4RAD, 4RAN, 4RAO, 4RAQ, 5BSK, 5BRN

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