Old Reynella is a metropolitan suburb of Adelaide, South Australia. It is located 20 km south of the Adelaide city centre in the north of the City of Onkaparinga.

The suburb is named after John Reynell, a pioneering South Australian winemaker. Reynell sold some farmland to create the town of Reynella which is the present location of the suburb Old Reynella. The Reynell name goes back to the very beginning of the wine industry in South Australia, when John Reynell planted some of the first vines in the infant colony in the area that was later to bear his name. This pioneer of the grape was born in 1809 of a Devonshire farming family. Shortly after his arrival in 1838 John Reynell established his property, situated 20 kilometres south of Adelaide and 5 kilometres east of Gulf St Vincent - the gateway to the McLaren Vale wine region.

The Reynella Winery is claimed to be the only winery in Australia that can use the name of a town as its registered brand because the winery was in existence before the town was established.

The Old Reynella area is the historical centre of the district and the original home of Reynella Primary School, before it was moved to its current site in Carew Fields in 1990. Old Reynella is also the historical home of the Hardy Wine Company.

Edge Church is located in Old Reynella at the former site of the Old Reynella Markets.

With the arrival of Governor Hindmarsh on the HMS Buffalo on 28 December 1836, the new private colony of South Australia was proclaimed. The state government was established through the formation of a private company in England known as the South Australia Company. Its Surveyor-General, William Light, was charged with the surveying of the land into 80-acre (32 ha) allotments ready for sale to the new settlers to South Australia. One of his team was John McLaren, who was responsible for surveying Sections B, C and D to the south of Adelaide. This task was completed in 1839 and the first survey maps were printed in 1840.

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