HuR

ELAVL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HI9, 4ED5, 4EGL, 4FXV
Identifiers
Aliases	ELAVL1, ELAV1, HUR, Hua, MelG, ELAV like RNA binding protein 1
External IDs	MGI: 1100851 HomoloGene: 20367 GeneCards: ELAVL1
Gene ontology Molecular function • protein homodimerization activity • mRNA 3'-UTR binding • protein binding • RNA binding • nucleic acid binding • double-stranded RNA binding • protein kinase binding • mRNA binding • AU-rich element binding • mRNA 3'-UTR AU-rich region binding Cellular component • cytoplasm • cytosol • membrane • nucleoplasm • nucleus • ribonucleoprotein complex Biological process • regulation of mRNA stability • regulation of stem cell population maintenance • positive regulation of translation • multicellular organism development • mRNA stabilization • 3'-UTR-mediated mRNA stabilization • mRNA splicing, via spliceosome • negative regulation of gene silencing by miRNA Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1994	15568
Ensembl	ENSG00000066044	ENSMUSG00000040028
UniProt	Q15717	P70372
RefSeq (mRNA)	NM_001419	NM_010485
RefSeq (protein)	NP_001410	NP_034615
Location (UCSC)	Chr 19: 7.96 – 8.01 Mb	Chr 8: 4.29 – 4.33 Mb
PubMed search

3HI9, 4ED5, 4EGL, 4FXV

1994

15568

ENSG00000066044

ENSMUSG00000040028

Q15717

P70372

NM_001419

NM_010485

NP_001410

NP_034615

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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