Htra2

HTRA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LCY, 2PZD
Identifiers
Aliases	HTRA2, Htra2, AI481710, Omi, Prss25, mnd2, PARK13, HtrA serine peptidase 2
External IDs	MGI: 1928676 HomoloGene: 113300 GeneCards: HTRA2
Gene ontology Molecular function • unfolded protein binding • protein binding • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity • peptidase activity Cellular component • integral component of membrane • cytosol • endoplasmic reticulum membrane • membrane • mitochondrial membrane • mitochondrial intermembrane space • endoplasmic reticulum • mitochondrion • CD40 receptor complex • cytoplasmic side of plasma membrane • chromatin • cytoskeleton • nucleus Biological process • cellular response to retinoic acid • cellular response to heat • positive regulation of cell death • ceramide metabolic process • cellular response to interferon-beta • regulation of multicellular organism growth • positive regulation of protein targeting to mitochondrion • execution phase of apoptosis • adult locomotory behavior • cellular response to growth factor stimulus • pentacyclic triterpenoid metabolic process • mitochondrion organization • negative regulation of cell cycle • neuron development • protein autoprocessing • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of cell death • cellular protein catabolic process • intrinsic apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of mitophagy • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of apoptotic process • forebrain development • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • response to herbicide • adult walking behavior • negative regulation of neuron death • apoptotic process • aging • proteolysis • positive regulation of mitochondrion organization • cellular response to oxidative stress • negative regulation of mitophagy in response to mitochondrial depolarization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27429	64704
Ensembl	ENSG00000115317	ENSMUSG00000068329
UniProt	O43464	Q9JIY5
RefSeq (mRNA)	NM_013247 NM_145074 NM_001321727 NM_001321728	NM_019752
RefSeq (protein)	NP_001308656 NP_001308657 NP_037379 NP_659540	NP_062726.3 NP_062726
Location (UCSC)	Chr 2: 74.53 – 74.53 Mb	Chr 6: 83.05 – 83.06 Mb
PubMed search

1LCY, 2PZD

27429

64704

ENSG00000115317

ENSMUSG00000068329

O43464

Q9JIY5

NM_013247
NM_145074
NM_001321727
NM_001321728

NM_019752

NP_001308656
NP_001308657
NP_037379
NP_659540

NP_062726.3
NP_062726

Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This protein is involved in caspase-dependent apoptosis and in Parkinson's disease.

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