Hsp27

HSPB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MJH, 3Q9P, 3Q9Q, 2N3J
Identifiers
Aliases	HSPB1, CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27, heat shock protein family B (small) member 1
External IDs	OMIM: 602195 MGI: 96240 HomoloGene: 1180 GeneCards: HSPB1
Gene ontology Molecular function • protein kinase C inhibitor activity • protein kinase binding • protein binding • protein kinase C binding • ubiquitin binding • identical protein binding • protein binding involved in protein folding • RNA binding Cellular component • nucleus • cytoskeleton • spindle • intracellular • cytosol • extracellular exosome • plasma membrane • Z disc • cytoplasm • contractile fiber • focal adhesion • proteasome complex • extracellular matrix • extracellular space • axon cytoplasm Biological process • regulation of translational initiation • regulation of mRNA stability • cellular response to vascular endothelial growth factor stimulus • negative regulation of protein serine/threonine kinase activity • positive regulation of endothelial cell chemotaxis • positive regulation of angiogenesis • retina homeostasis • movement of cell or subcellular component • platelet aggregation • intracellular signal transduction • negative regulation of apoptotic signaling pathway • regulation of autophagy • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • positive regulation of interleukin-1 beta production • vascular endothelial growth factor receptor signaling pathway • positive regulation of blood vessel endothelial cell migration • response to unfolded protein • negative regulation of protein kinase activity • regulation of I-kappaB kinase/NF-kappaB signaling • response to virus • negative regulation of apoptotic process • positive regulation of tumor necrosis factor biosynthetic process • regulation of protein phosphorylation • chaperone-mediated protein folding • anterograde axonal protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3315	15507
Ensembl	ENSG00000106211	ENSMUSG00000004951
UniProt	P04792	P14602
RefSeq (mRNA)	NM_001540	NM_013560
RefSeq (protein)	NP_001531	NP_038588.2 NP_038588
Location (UCSC)	Chr 7: 76.3 – 76.3 Mb	Chr 5: 135.89 – 135.89 Mb
PubMed search

4MJH, 3Q9P, 3Q9Q, 2N3J

3315

15507

ENSG00000106211

ENSMUSG00000004951

P04792

P14602

NM_001540

NM_013560

NP_001531

NP_038588.2
NP_038588

Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene.

Hsp27 is a chaperone of the sHsp (small heat shock protein) group among ubiquitin, α-crystallin, Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction.

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Wikipedia