The Na Champassak family (Lao: ນະ ຈຳປາສັກ; Thai: ณ จัมปาศักดิ์, rtgs: Na Champasak) were an important Lao Royal family, descendants of Chao Yuttithammathon (Kham Souk), the 11th King of the Kingdom of Champassak whose prominent members include Prince Boun Oum Na Champassak and Prince Sisouk na Champassak. The Na Champassak family was the ruling house of the former Kingdom of Champassak, with territories reaching on both banks of the Mekong river.
To repel the attempts of Setthathirath II, nephew of King Suliyavongsa, to unify the kingdom of Lanxang to include Vientiane and Loungprabang, the King of Loungprabang requested aid from Siam. The King of Siam therefore granted Loungprabang independence from Lanxang. Following in the footsteps of his cousin the King of Loungprabang, the Prince Nokasat Song, refused to acknowledge the rule of Setthathirath II. A grandson of King Suliyavongsa, the prince had left Vientiane for Southern Laos upon the return of Setthathirath II. He asked the King of Siam to recognize Champassak's independence from Lanxang. Lanxang was thus split yet even further into a total of three small kingdoms.
During the rule of King Anouvong of the Kingdom of Vientiane, Anouvong placed his son Prince Nyô on the throne of Champassak. During King Anouvong's rebellion against Siam, the former royals of Champassak started a rebellion against Prince Nyô while he was fighting against Siamese forces in Issan. Returning to Champassak, Prince Nyô saw a rebellion taking place and barely escaped out of the city. This escape was cut short after the former rulers tracked down Prince Nyô and handed him over to the Siamese. The King of Siam returned the former royal family to rule over Champassak.
The name Champassak was given by Vajiravudh, the King of Siam, to descendants of Chao Yuttithammathon (Kham Souk), the 11th king of the Kingdom of Champassak. They took their name from the city of Champassak, prefixed by the nobiliary particle signifying of a former kingdom or tributary state of Siam. They are descended from the rulers of the Kingdom of Champassak and are also members of the Khun Lo Dynasty, which was established by Khun Lo. Originally, it was transliterated in English as Na Champasakdi. During most of the 19th century the Kingdom of Champassak were tributary to Bangkok but was not an integral part of Siam.