Hormone-sensitive lipase
| LIPE | ||||||
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| Identifiers | ||||||
| Aliases | LIPE, AOMS4, FPLD6, HSL, LHS, lipase E, hormone sensitive type | |||||
| External IDs | MGI: 96790 HomoloGene: 3912 GeneCards: LIPE | |||||
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| Species | Human | Mouse | ||||
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| Location (UCSC) | Chr 19: 42.4 – 42.43 Mb | Chr 7: 25.38 – 25.4 Mb | ||||
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| Hormone-sensitive lipase (HSL) N-terminus | |||||||||
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| Symbol | HSL_N | ||||||||
| Pfam | PF06350 | ||||||||
| InterPro | IPR010468 | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
NP_001034596.1
NP_034849.2
NP_001034596
NP_034849
Hormone-sensitive lipase (EC 3.1.1.79, HSL) also previously known as cholesteryl ester hydrolase (CEH) is an enzyme that, in humans, is encoded by the LIPE gene.
HSL is an intracellular neutral lipase that is capable of hydrolyzing a variety of esters. The enzyme has a long and a short form. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
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