Homeobox protein NANOG

NANOG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KT0
Identifiers
Aliases	NANOG, entrez:79923, Nanog
External IDs	OMIM: 607937 MGI: 1919200 HomoloGene: 78027 GeneCards: NANOG
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • protein binding • transcription corepressor activity Cellular component • nucleolus • nucleus • nucleoplasm Biological process • regulation of gene expression • stem cell population maintenance • regulation of cell differentiation • multicellular organism development • cell differentiation • cell proliferation • regulation of transcription, DNA-templated • somatic stem cell population maintenance • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • endodermal cell fate specification • negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79923	71950
Ensembl	ENSG00000111704	ENSMUSG00000012396
UniProt	Q9H9S0	Q80Z64
RefSeq (mRNA)	NM_001297698 NM_024865	NM_028016 NM_001289828 NM_001289830 NM_001289831
RefSeq (protein)	NP_001284627 NP_079141	NP_001276757.1 NP_001276759.1 NP_001276760.1 NP_082292.1 NP_001276757 NP_001276759 NP_001276760 NP_082292
Location (UCSC)	Chr 12: 7.79 – 7.8 Mb	Chr 6: 122.71 – 122.71 Mb
PubMed search

2KT0

79923

71950

ENSG00000111704

ENSMUSG00000012396

Q9H9S0

Q80Z64

NM_001297698
NM_024865

NM_028016
NM_001289828
NM_001289830
NM_001289831

NP_001284627
NP_079141

NP_001276759
NP_001276760
NP_082292

NANOG (pron. nanOg) is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells. In humans, this protein is encoded by the NANOG gene.

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