The history of the Jews in Cyprus dates back to the 3rd century BC, after trade relations had been established between Cyprus and the Land of Israel. The Jews had close relationships with many of the other religious groups on the island and were seen favourably by the Romans. During the war over the city of Ptolemais between Alexander Jannaeus and Ptolemy IX Lathyros, King of Cyprus, many Jews were killed. During the war the Jewish citizens remained committed in their allegiance to King Lathyros.
The Jews lived well in Cyprus during the Roman rule. During this period, Christianity was preached in Cyprus among the Jews at an early date, St Paul being the first, and Barnabas, a native of Cyprus, the second. They attempted to convert the Jews to Christianity under the ideas of Jesus. Under the leadership of Artemion, the Cypriot Jews participated in the great rebellion against the Romans ruled by Trajan in 117 AD. and they are reported by Dio Cassius to have massacred 240,000 Greeks. In punishment a severe law was enacted, according to which no Jew was allowed to land on Cypriot soil, not even in case of shipwreck. After a few years of calm, the Jewish communities began to grow and thrive once again in Cyprus. In 610, however, the Jews again participated in the uprising against the Greeks under the rule of Heraclius. In 646, and again in 1154, Cyprus was devastated by the Arabs. Nevertheless communities of Romaniote Jews from the Byzantine period are known.
Jewish merchants were active during this time at the port city of Famagusta.
Cyprus was conquered by the Ottoman Empire after their war with Venice. During Ottoman rule the Jewish community of Cyprus thrived due to the influx of Sephardi Jews from Ottoman lands, who had emigrated en masse to the Ottoman territories after expulsion from Spain in 1492. Famagusta became the main center of the Ottoman Jewish community in Cyprus.