Hisham ibn al-Mughirah was from the Banu Makhzum sub-clan of the Quraish tribe and was a contemporary of Muhammad. He was a person of high rank among the Quraish and he was one of the commanders in the Sacrilegious War.
He was the son of Mughirah ibn Abd-Allah, one of the Leaders of Quraish. One of his daughters was Khantamah, who was the mother of Umar. By his wife Asma bint Mukharraba, he was the father of Abu Jahl, the famous opponent of Muhammad. His brother was Walid ibn al-Mughira, making him an uncle of the famous Muslim general Khalid ibn al-Walid.
It is believed that he died in 598.