Hippolyte Destailleur (27 September 1822 – 17 November 1893) was a French architect, interior designer, and collector. He is noted for his designs and restoration work for great châteaux in France and in England, as well as his collection of books, prints, and drawings, covering French artists of the 18th and 19th centuries, much of which is now in the Cabinet des Estampes of the Bibliothèque Nationale, Paris (Destailleur Collection).
Born Hippolyte-Alexandre-Gabriel-Walter Destailleur in Paris, he was the son of François-Hippolyte Destailleur (born Paris, 22 March 1787; died Paris, 15 February 1852), also a noted French architect, who studied with Charles Percier and became architect to the Ministère de la Justice in 1819. Hippolyte studied with François-René Leclère at the École des Beaux-Arts in Paris (1842–1846), after which he worked with his father and with Étienne-Hippolyte Godde. In 1853 he became the head of the family practice and succeeded his father at the Ministère de la Justice.
Hippolyte Destailleur became a fashionable architect, catering to rich and titled clients. He mimicked French styles of the 16th to 18th centuries, distinguishing himself from many of his contemporaries, who favored medieval, Italian Renaissance, or antique models. Among his creations were: Rococo Revival interiors for the Hôtel de Pourtalès in Paris (1865); the town house of Graf Hans Heinric von Pless[] in Berlin (1874–1876); and the Palais Rothschild of Baron Albert de Rothschild in Vienna (1876–1882).