Hepatic lipase

LIPC
Identifiers
Aliases	LIPC, HDLCQ12, HL, HTGL, LIPH, lipase C, hepatic type
External IDs	OMIM: 151670 MGI: 96216 HomoloGene: 199 GeneCards: LIPC
Gene ontology Molecular function • heparin binding • lipase activity • triglyceride lipase activity • phospholipase activity • carboxylic ester hydrolase activity • hydrolase activity • low-density lipoprotein particle binding • apolipoprotein binding Cellular component • endoplasmic reticulum lumen • extracellular region • high-density lipoprotein particle • extracellular space Biological process • phosphatidylcholine catabolic process • lipid digestion • lipid metabolic process • cholesterol transport • cholesterol metabolic process • intermediate-density lipoprotein particle remodeling • triglyceride catabolic process • lipid catabolic process • fatty acid biosynthetic process • cholesterol homeostasis • triglyceride homeostasis • reverse cholesterol transport • low-density lipoprotein particle remodeling • chylomicron remnant clearance • very-low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3990	15450
Ensembl	ENSG00000166035	ENSMUSG00000032207
UniProt	P11150	P27656
RefSeq (mRNA)	NM_000236	NM_008280 NM_001324472 NM_001324473
RefSeq (protein)	NP_000227	NP_032306.2 NP_001311401.1 NP_001311402.1 NP_001311401 NP_001311402 NP_032306
Location (UCSC)	Chr 15: 58.41 – 58.57 Mb	Chr 9: 70.8 – 70.95 Mb
PubMed search

3990

15450

ENSG00000166035

ENSMUSG00000032207

P11150

P27656

NM_000236

NM_008280
NM_001324472
NM_001324473

NP_000227

NP_032306

Hepatic lipase, also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of fats. It is expressed in the liver and adrenal glands.

One of the principal functions of hepatic lipase is to convert intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL).

LIPC encodes hepatic triglyceride lipase (HTGL), which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

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Wikipedia