Henry Powle (18 October 1630 – 21 November 1692) was an English lawyer and politician who sat in the House of Commons at various times between 1660 and 1690. He was Speaker of the House of Commons from January 1689 to February 1689. He was also Master of the Rolls.
Born at Shottesbrook in 1630, he was second son of Henry Powle, who was sheriff for Berkshire in 1633, by his wife Katherine, daughter of Matthew Herbert of Monmouth. He matriculated from Christ Church, Oxford, on 16 December 1646. He was admitted to Lincoln's Inn on 11 May 1647, and became a barrister in 1654 and bencher in 1659. In April 1660 he was elected Member of Parliament for Cirencester in the Convention Parliament.
On 3 January 1671, Powle was elected MP for Cirencester again in the Cavalier Parliament. At the time he held property at Williamstrop or Quenington in Gloucestershire, and was usually described as of the latter place. He first appeared in debate in February 1673, when he attacked Lord-chancellor Shaftesbury's practice of issuing writs for by-elections during the recess without the speaker's warrant. As a result of the debate all the elections were declared void, 6 February 1673. Subsequently he opposed the Declaration of Indulgence, Charles II of England's measure of religious toleration, wishing disabilities for Catholics and dissenters to continue.