Henry Fane (16 October 1703 – 31 May 1777) of Wormsley nr. Watlington, Oxfordshire, was one of the chief clerks of the Board of Treasury, one of the chief clerks to the Privy Council, and a Member of Parliament.
Henry Fane was the grandson of Francis Fane, a Restoration dramatist, and son of Henry Fane (1669–1726) of Brympton and Anne, sister and coheir of John Scrope of Wormsley.
Henry Fane, was one of the chief clerks of the Board of Treasury from 1742 until July 1764, and one of the chief clerks to the Privy Council from 1756 until 1764, and a commissioner for the duties on salt.
In 1757, on the death of his brother Francis, Henry was elected for Lyme Regis; was re-elected 1774, and died 31 May 1777.
On 17 July 1735, Henry Fane married Charlotte Rowe, only daughter of Nicholas Rowe, Esq. the Poet Laureate. She died in 1739, at twenty-three, and was buried in Westminster Abbey. They had a daughter, Charlotte, who married Sir William St. Quintin of Harpham in Yorkshire, 15 May 1758. She died on 17 April 1762, and is buried at Harpham.
Fane married for the second time on 20 May 1742. He married Anne Wynne, daughter of Dr. John Wynne, late bishop of Bath and Wells, with whom he had one daughter, Mary, who on 27 November 1765, married Sir Thomas Stapleton, of Grey's-court in Oxfordshire, Bart, (see Stapleton baronets), and was mother of Lord le Despencer (see Baron le Despencer).