Francis Fane KC (c. 1698 – 28 May 1757) of Brympton, nr. Yeovil, Somerset, and later Wormsley, Oxfordshire was a commissioner for trade and the Plantations, and a British Member of Parliament.
Francis Fane was educated at King's College, Cambridge, he graduated in 1715, attended the Middle Temple, and was called to the bar in 1721. As the eldest son he succeed to the estate of his father, Henry Fane, in 1726. The next year he became a King's Counsellor and a Middle Temple bencher.
Fane was appointed standing council to the Board of Trade and Plantations in 1725, a position he held until 1746. He sat in several parliaments for more than one constituency. He represented Taunton in Somersetshire in his first parliament, that which first sat for on business, 27 January 1728 (N.S.). He also represented the same seat in the parliament summoned to meet, 13 June 1734; and in that summoned to meet, 25 June 1741, for Petersfield; Between 13 May 1729 and her death in 1737 he was also Solicitor-General to Queen Caroline, and between 1739 and 1751 he was chairman of the ways and means committee.
On 1746 being constituted one of the commissioners for the Board of Trade and the Plantations, he was re-elected on a new writ to Parliament. In the parliament, which sat first on business, 12 November 1747, he was chosen for Ilchester. He inherited some estates from his maternal uncle John Scrope in 1752. He resigned his place as a commissioner of Trade and the Plantations, in April 1756.