Heme oxygenase 1

HMOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ
Identifiers
Aliases	HMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDs	OMIM: 141250 MGI: 96163 HomoloGene: 31075 GeneCards: HMOX1
Gene ontology Molecular function • phospholipase D activity • protein homodimerization activity • heme oxygenase (decyclizing) activity • metal ion binding • signal transducer activity • heme binding • protein binding • enzyme binding • oxidoreductase activity Cellular component • cytosol • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • nucleolus • endoplasmic reticulum • caveola • perinuclear region of cytoplasm • nucleus • extracellular space Biological process • negative regulation of neuron apoptotic process • apoptotic process • cellular iron ion homeostasis • negative regulation of smooth muscle cell proliferation • cellular response to heat • GO:0007242 intracellular signal transduction • negative regulation of mast cell cytokine production • response to hypoxia • excretion • low-density lipoprotein particle clearance • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • positive regulation of chemokine biosynthetic process • small GTPase mediated signal transduction • negative regulation of DNA binding • response to nicotine • iron ion homeostasis • cell death • heme oxidation • negative regulation of mast cell degranulation • cellular response to cadmium ion • regulation of angiogenesis • negative regulation of muscle cell apoptotic process • response to oxidative stress • negative regulation of sequence-specific DNA binding transcription factor activity • cellular response to nutrient • positive regulation of angiogenesis • response to estrogen • wound healing involved in inflammatory response • regulation of blood pressure • heme catabolic process • erythrocyte homeostasis • regulation of sequence-specific DNA binding transcription factor activity • cellular response to arsenic-containing substance • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • angiogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • endothelial cell proliferation • positive regulation of I-kappaB kinase/NF-kappaB signaling • smooth muscle hyperplasia • protein homooligomerization • oxidation-reduction process • negative regulation of leukocyte migration • cellular response to hypoxia • response to hydrogen peroxide • negative regulation of cell proliferation • heme metabolic process • positive regulation of smooth muscle cell proliferation • regulation of transcription from RNA polymerase II promoter in response to iron • positive regulation of apoptotic process • cellular response to cisplatin • positive regulation of macroautophagy • negative regulation of vascular smooth muscle cell proliferation • negative regulation of epithelial cell apoptotic process • liver regeneration • negative regulation of macroautophagy • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3162	15368
Ensembl	ENSG00000100292	ENSMUSG00000005413
UniProt	P09601	P14901
RefSeq (mRNA)	NM_002133	NM_010442
RefSeq (protein)	NP_002124	NP_034572
Location (UCSC)	Chr 22: 35.38 – 35.39 Mb	Chr 8: 75.09 – 75.1 Mb
PubMed search

1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ

3162

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