Harry Stone Mosher
| Harry Stone Mosher | |
|---|---|
| Born |
August 31, 1915 Salem, Oregon, United States |
| Died | March 2, 2001 (aged 85) Stanford, California, United States |
| Nationality | American |
| Institutions | Stanford University |
| Alma mater | Willamette University, Pennsylvania State University |
| Doctoral advisor | Frank C. Whitmore |
| Doctoral students |
Charles P. Haber, Lois J. Durham, Elizabeth Parker Burrows, Melvin Look, Roy C. De Selms, Victor Althouse, Melancthon Brown, Robert Dummel, Dorothy M. Feigl, Betty McFarland, Joel Schmiegel, Betty Ann Winter Stephenson, Carolyn Lucille Heutter Fisher, Natalie Lewis McClure, Alexandra Baran Shortt |
| Known for | Mosher's acid |
Charles P. Haber, Lois J. Durham, Elizabeth Parker Burrows, Melvin Look, Roy C. De Selms, Victor Althouse, Melancthon Brown, Robert Dummel, Dorothy M. Feigl, Betty
Harry Stone Mosher (August 31, 1915 – March 2, 2001) was an American chemist and the discoverer of Mosher's acid .
Mosher attended Willamette University in Salem, Oregon, where he received a bachelor's degree in chemistry in 1937. He went on to Oregon State University, where he earned a master's degree in 1938. He then returned to Willamette to teach for one year. In 1939, he continued his graduate work at Pennsylvania State University under the mentorship of Frank C. Whitmore, a renowned organic chemist. In 1942, Mosher completed his PhD in organic chemistry. He remained at Pennsylvania State as an assistant professor, supervising research on synthetic anti-malarial drugs for the National Research Council and the production of DDT with the War Production Board. In 1944, Mosher married Carol Walker, a fellow chemistry graduate student at the university. Three years later, Mosher accepted an assistant professorship at Stanford University in the Department of Chemistry, and he and his wife moved to California for the position. That same year his wife Carol joined the staff of the Stanford Research Institute, later becoming senior organic chemist.
While at Stanford, Mosher taught organic chemistry and conducted research in natural products chemistry and stereochemistry. He and his graduate student Melanchton Brown identified a deadly toxin produced by the California newt living in Stanford's Lake Lagunita, calling it tarichatoxin. They soon discovered that it was the same toxin produced by the puffer fish, used in a rare type of sushi that if prepared incorrectly could paralyze and kill human diners. Mosher determined the structure of the toxin, which is known as tetrodotoxin. Mosher worked on many other natural products including both plant pigments and toxic substances.
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