HYAL3

HYAL3
Identifiers
Aliases	HYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3
External IDs	MGI: 1330288 HomoloGene: 2626 GeneCards: HYAL3
Gene location (Human) Chr. Chromosome 3 (human) Band n/a Start 50,292,831 bp End 50,299,468 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band n/a Start 107,580,818 bp End 107,587,359 bp
Gene ontology Molecular function • hydrolase activity, acting on glycosyl bonds • protein binding • hyaluronoglucuronidase activity • virus receptor activity • hydrolase activity • catalytic activity • hyalurononglucosaminidase activity Cellular component • extracellular region • cytoplasmic vesicle • lysosome Biological process • cellular response to UV-B • cartilage development • carbohydrate metabolic process • response to antibiotic • cellular response to tumor necrosis factor • metabolic process • cellular response to interleukin-1 • inflammatory response • response to virus • hyaluronan catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8372	109685
Ensembl	ENSG00000186792	ENSMUSG00000036091
UniProt	O43820	Q8VEI3
RefSeq (mRNA)	NM_003549 NM_001200029 NM_001200030 NM_001200031 NM_001200032	NM_178020
RefSeq (protein)	NP_001186958 NP_001186959 NP_001186960 NP_001186961 NP_003540	NP_821139
Location (UCSC)	Chr 3: 50.29 – 50.3 Mb	Chr 3: 107.58 – 107.59 Mb
PubMed search

8372

109685

ENSG00000186792

ENSMUSG00000036091

O43820

Q8VEI3

NM_003549
NM_001200029
NM_001200030
NM_001200031
NM_001200032

NM_178020

NP_001186958
NP_001186959
NP_001186960
NP_001186961
NP_003540

NP_821139

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.

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