HTR3A

HTR3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PIR
Identifiers
Aliases	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
External IDs	MGI: 96282 HomoloGene: 671 GeneCards: HTR3A
Gene ontology Molecular function • protein binding • ligand-gated ion channel activity • serotonin binding • extracellular ligand-gated ion channel activity • serotonin-gated cation-selective channel activity • ion channel activity Cellular component • cytoplasm • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • axon • cell junction • neuronal cell body • serotonin-activated cation-selective channel complex • cleavage furrow Biological process • response to cocaine • cellular response to growth factor stimulus • ion transport • ion transmembrane transport • response to ethanol • transport • positive regulation of ion transmembrane transporter activity • cation transmembrane transport • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3359	15561
Ensembl	ENSG00000166736	ENSMUSG00000032269
UniProt	P46098	P23979
RefSeq (mRNA)	NM_000869 NM_001161772 NM_213621	NM_001099644 NM_013561
RefSeq (protein)	NP_000860 NP_001155244 NP_998786	NP_001093114 NP_038589
Location (UCSC)	Chr 11: 113.97 – 113.99 Mb	Chr 9: 48.9 – 48.91 Mb
PubMed search

4PIR

3359

15561

ENSG00000166736

ENSMUSG00000032269

P46098

P23979

NM_000869
NM_001161772
NM_213621

NM_001099644
NM_013561

NP_000860
NP_001155244
NP_998786

NP_001093114
NP_038589

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.

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