HSPA8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ

Identifiers

Aliases

HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8

External IDs

OMIM: 600816 MGI: 105384 HomoloGene: 68524 GeneCards: HSPA8

Gene ontology
Molecular function	• ATPase activity, coupled • nucleotide binding • heat shock protein binding • unfolded protein binding • phosphatidylserine binding • C3HC4-type RING finger domain binding • protein binding • MHC class II protein complex binding • enzyme binding • G-protein coupled receptor binding • ATP binding • ubiquitin protein ligase binding • ATPase activity • RNA binding • cadherin binding
Cellular component	• cytoplasm • cytosol • late endosome • blood microparticle • membrane • focal adhesion • ubiquitin ligase complex • melanosome • myelin sheath • plasma membrane • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • intracellular ribonucleoprotein complex • intracellular • Prp19 complex • nucleoplasm • lysosomal membrane • lysosomal lumen • nucleolus • spliceosomal complex • lumenal side of lysosomal membrane • extracellular exosome • nucleus • presynapse • extracellular matrix • extracellular region • extracellular space • secretory granule lumen • ficolin-1-rich granule lumen
Biological process	• chaperone-mediated autophagy • mRNA splicing, via spliceosome • late endosomal microautophagy • regulation of transcription, DNA-templated • regulation of protein stability • regulation of mRNA stability • positive regulation of mRNA splicing, via spliceosome • cellular response to starvation • mRNA processing • chaperone-mediated autophagy translocation complex disassembly • transcription, DNA-templated • chaperone mediated protein folding requiring cofactor • regulation of cell cycle • regulation of protein complex stability • ATP metabolic process • response to unfolded protein • chaperone-mediated protein transport involved in chaperone-mediated autophagy • clathrin coat disassembly • protein folding • protein refolding • regulation of cellular response to heat • viral process • negative regulation of transcription, DNA-templated • neurotransmitter secretion • regulation of protein complex assembly • negative regulation of supramolecular fiber organization • regulation of protein import • RNA splicing • protein methylation • neutrophil degranulation • modulation by host of viral process • positive regulation by host of viral genome replication • membrane organization • protein targeting to lysosome involved in chaperone-mediated autophagy
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3312


15481

Ensembl


ENSG00000109971


ENSMUSG00000015656

UniProt


P11142


P63017

RefSeq (mRNA)


NM_006597 NM_153201


NM_031165

RefSeq (protein)


NP_006588 NP_694881


NP_112442.2 NP_112442

Location (UCSC)

Chr 11: 123.06 – 123.06 Mb

Chr 9: 40.8 – 40.81 Mb

PubMed search

3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ

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