HSD3B2

HSD3B2
Identifiers
Aliases	HSD3B2, HSD3B, HSDB, SDR11E2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
External IDs	MGI: 96233 HomoloGene: 69149 GeneCards: HSD3B2
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • isomerase activity • catalytic activity • oxidoreductase activity • 3-beta-hydroxy-delta5-steroid dehydrogenase activity • steroid delta-isomerase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • mitochondrial membrane • membrane • mitochondrial intermembrane space • smooth endoplasmic reticulum membrane • endoplasmic reticulum • mitochondrion • mitochondrial inner membrane Biological process • androgen biosynthetic process • glucocorticoid biosynthetic process • mineralocorticoid biosynthetic process • metabolic process • oxidation-reduction process • steroid biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3284	15492
Ensembl	ENSG00000203859	ENSMUSG00000027871
UniProt	P26439 Q5QP01	P24815
RefSeq (mRNA)	NM_001166120 NM_000198	NM_008293 NM_001304800
RefSeq (protein)	NP_000189 NP_001159592	NP_001291729.1 NP_032319.1 NP_001291729 NP_032319
Location (UCSC)	Chr 1: 119.41 – 119.42 Mb	Chr 3: 98.85 – 98.86 Mb
PubMed search

3284

15492

ENSG00000203859

ENSMUSG00000027871

P26439
Q5QP01

P24815

NM_001166120
NM_000198

NM_008293
NM_001304800

NP_000189
NP_001159592

NP_001291729.1
NP_032319.1
NP_001291729
NP_032319

HSD3B2 is a human gene that encodes for 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type II or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2. It is expressed principally in steroidogenic tissues and is essential for steroid hormone production. A notable exception is the placenta, where HSD3B1 is critical for progesterone production by this tissue.

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Wikipedia