HOXB8

Identifiers

HOXB8, HOX2, HOX2D, Hox-2.4, homeobox B8

External IDs

MGI: 96189 HomoloGene: 7768 GeneCards: HOXB8

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • DNA binding
Cellular component	• nucleus • nucleoplasm
Biological process	• embryonic skeletal system morphogenesis • multicellular organism development • adult locomotory behavior • grooming behavior • sensory perception of pain • skeletal system morphogenesis • dorsal spinal cord development • regulation of transcription, DNA-templated • negative regulation of myeloid cell differentiation • transcription, DNA-templated • anterior/posterior pattern specification
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3218


15416

Ensembl


ENSG00000120068


ENSMUSG00000056648

UniProt


P17481


P09632

RefSeq (mRNA)


NM_024016


NM_010461

RefSeq (protein)


NP_076921


NP_034591.1 NP_034591

Location (UCSC)

Chr 17: 48.61 – 48.61 Mb

Chr 11: 96.28 – 96.29 Mb

PubMed search

NP_034591.1
NP_034591

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results is a reduction of compulsive grooming.

...
Wikipedia