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HNRPA2B1

HNRNPA2B1
Protein HNRPA2B1 PDB 1x4b.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HNRNPA2B1, HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1, heterogeneous nuclear ribonucleoprotein A2/B1
External IDs MGI: 104819 HomoloGene: 22992 GeneCards: HNRNPA2B1
RNA expression pattern
PBB GE HNRPA2B1 205292 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002137
NM_031243

NM_016806
NM_182650

RefSeq (protein)

NP_002128
NP_112533

NP_058086
NP_872591

Location (UCSC) Chr 7: 26.19 – 26.2 Mb Chr 6: 51.46 – 51.47 Mb
PubMed search

1X4B

NM_002137
NM_031243

NM_016806
NM_182650

NP_002128
NP_112533

NP_058086
NP_872591

Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene.

HNRNPA2B1 gene contains 12 exons, including a B1 protein specific 36-nucleotide mini-exon. The entire length of intron/exon organization of HNRNPA2B1 is identical to that of the HNRNPA1 gene which indicates a common origin by gene duplication.

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33.


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Wikipedia

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