HNRNPL

HNRNPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3R27, 3TO8
Identifiers
Aliases	HNRNPL, HNRPL, hnRNP-L, P/OKcl.14, heterogeneous nuclear ribonucleoprotein L
External IDs	MGI: 104816 HomoloGene: 1174 GeneCards: HNRNPL
Gene ontology Molecular function • transcription regulatory region DNA binding • protein binding • pre-mRNA intronic binding • nucleic acid binding • RNA binding • mRNA 3'-UTR binding • mRNA CDS binding Cellular component • cytoplasm • ribonucleoprotein granule • intracellular ribonucleoprotein complex • extracellular exosome • membrane • nucleus • nucleoplasm • cytosol • pronucleus • perinuclear region of cytoplasm Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA processing • gene expression • regulation of alternative mRNA splicing, via spliceosome • circadian rhythm • cellular response to amino acid starvation • positive regulation of translation • negative regulation of mRNA splicing, via spliceosome • response to peptide • positive regulation of mRNA binding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3191	15388
Ensembl	n/a	ENSMUSG00000015165
UniProt	P14866	Q8R081
RefSeq (mRNA)	NM_001005335 NM_001533	NM_177301
RefSeq (protein)	NP_001005335 NP_001524	NP_796275.3 NP_796275
Location (UCSC)	Chr 19: 38.84 – 38.85 Mb	Chr 7: 28.81 – 28.82 Mb
PubMed search

3R27, 3TO8

3191

15388

n/a

ENSMUSG00000015165

P14866

Q8R081

NM_001005335
NM_001533

NM_177301

NP_001005335
NP_001524

NP_796275.3
NP_796275

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

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Wikipedia