HNF4A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1PZL, 3CBB, 3FS1, 4B7W, 4IQR

Identifiers

Aliases

HNF4A, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, FRTS4, Hepatocyte nuclear factor 4 alpha

External IDs

MGI: 109128 HomoloGene: 395 GeneCards: HNF4A

Genetically Related Diseases

type 2 diabetes mellitus

Targeted by Drug

linoleic acid

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • RNA polymerase II activating transcription factor binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcription regulatory region DNA binding • receptor binding • RNA polymerase II core promoter sequence-specific DNA binding • fatty acid binding • protein homodimerization activity
Cellular component	• nucleus • cytoplasm • nucleoplasm
Biological process	• triglyceride homeostasis • ornithine metabolic process • phospholipid homeostasis • regulation of transcription, DNA-templated • SMAD protein signal transduction • glucose homeostasis • regulation of insulin secretion • lipid metabolic process • regulation of transcription from RNA polymerase II promoter • signal transduction involved in regulation of gene expression • sex differentiation • blood coagulation • response to glucose • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of cholesterol homeostasis • regulation of lipid metabolic process • intracellular receptor signaling pathway • regulation of growth hormone receptor signaling pathway • negative regulation of cell growth • lipid homeostasis • xenobiotic metabolic process • transcription initiation from RNA polymerase II promoter • regulation of gastrulation • steroid hormone mediated signaling pathway • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3172


15378

Ensembl


ENSG00000101076


ENSMUSG00000017950

UniProt


P41235


P49698

RefSeq (mRNA)

NM_000457 NM_001030003 NM_001030004 NM_001258355 NM_001287182
NM_001287183 NM_001287184 NM_175914 NM_178849 NM_178850


NM_008261 NM_001312906 NM_001312907

RefSeq (protein)

NP_000448 NP_001025174 NP_001025175 NP_001245284 NP_001274111
NP_001274112 NP_001274113 NP_787110 NP_849180 NP_849181


NP_032287.2 NP_001299835 NP_001299836 NP_032287

Location (UCSC)

Chr 20: 44.36 – 44.43 Mb

Chr 2: 163.51 – 163.57 Mb

PubMed search

1PZL, 3CBB, 3FS1, 4B7W, 4IQR

NM_001287183
NM_001287184
NM_175914
NM_178849
NM_178850

NM_008261
NM_001312906
NM_001312907

NP_001274112
NP_001274113
NP_787110
NP_849180
NP_849181

...
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