HLA-G

HLA-G
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3KYO, 1YDP, 2D31, 2DYP, 3BZE, 3CDG, 3CII, 3KYN
Identifiers
Aliases	HLA-G, MHC-G, HLA-G, major histocompatibility complex, class I, G
External IDs	MGI: 95915 HomoloGene: 133255 GeneCards: HLA-G
Gene ontology Molecular function • protein homodimerization activity • receptor binding • peptide antigen binding Cellular component • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • membrane • Golgi membrane • plasma membrane • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • recycling endosome membrane Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • positive regulation of tolerance induction • positive regulation of interleukin-12 production • interferon-gamma-mediated signaling pathway • immune system process • positive regulation of regulatory T cell differentiation • positive regulation of T cell tolerance induction • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • cellular defense response • negative regulation of T cell proliferation • negative regulation of immune response • type I interferon signaling pathway • regulation of immune response • immune response-inhibiting cell surface receptor signaling pathway • negative regulation of dendritic cell differentiation • antigen processing and presentation of peptide antigen via MHC class I Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3135	14991
Ensembl	n/a	ENSMUSG00000016206
UniProt	P17693	n/a
RefSeq (mRNA)	NM_002127	NM_013819
RefSeq (protein)	NP_002118	n/a
Location (UCSC)	Chr 6: 29.83 – 29.83 Mb	Chr 17: 37.27 – 37.27 Mb
PubMed search

3KYO, 1YDP, 2D31, 2DYP, 3BZE, 3CDG, 3CII, 3KYN

3135

14991

n/a

ENSMUSG00000016206

P17693

n/a

NM_002127

NM_013819

NP_002118

n/a

HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene.

HLA-G belongs to the HLA nonclassical class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. Exon 7 and 8 are not translated due to a stop codon present in exon 6.

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Wikipedia