HLA-F

HLA-F
Identifiers
Aliases	HLA-F, CDA12, HLA-5.4, HLA-CDA12, HLA-F, major histocompatibility complex, class I, F
External IDs	MGI: 3779381 HomoloGene: 133121 GeneCards: HLA-F
Gene ontology Molecular function • TAP2 binding • TAP1 binding • receptor binding • peptide antigen binding Cellular component • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • membrane • Golgi membrane • plasma membrane • cell surface • endoplasmic reticulum • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • recycling endosome membrane Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • type I interferon signaling pathway • regulation of immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3134	100529082
Ensembl	n/a	ENSMUSG00000079492
UniProt	P30511	n/a
RefSeq (mRNA)	NM_001098478 NM_001098479 NM_018950	NM_001199967
RefSeq (protein)	NP_001091948 NP_001091949 NP_061823	n/a
Location (UCSC)	Chr 6: 29.72 – 29.74 Mb	Chr 17: 36.06 – 36.06 Mb
PubMed search

3134

100529082

n/a

ENSMUSG00000079492

P30511

n/a

NM_001098478
NM_001098479
NM_018950

NM_001199967

NP_001091948
NP_001091949
NP_061823

n/a

HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene.

The Major Histocompatibility Complex (MHC) is a group of cell surface proteins that in humans is also called the Human Leukocyte Antigen (HLA) complex. These proteins are encoded by a cluster of genes known as the HLA locus. The HLA locus occupies a ~ 3Mbp stretch that is located on the short arm of chromosome 6, specifically on 6p21.1-21.3. The MHC proteins are classified into three main categories, namely class I, II, and III. There are over 140 genes within the HLA locus and they are often called HLA genes.HLA-A, B, and C are the classical class I genes and HLA-E, F and G are the nonclassical class I genes. The protein encoded from the gene HLA-F was originally isolated from the human lymphoblastoid cell line 721.

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Wikipedia