HLA-E

HLA-E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG
Identifiers
Aliases	HLA-E, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
External IDs	OMIM: 143010 MGI: 95957 HomoloGene: 134018 GeneCards: HLA-E
Gene ontology Molecular function • beta-2-microglobulin binding • MHC class I protein binding • receptor binding • natural killer cell lectin-like receptor binding • peptide antigen binding Cellular component • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • membrane • MHC class Ib protein complex • Golgi membrane • plasma membrane • cell surface • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • extracellular exosome • recycling endosome membrane Biological process • antigen processing and presentation • adaptive immune response • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • CD8-positive, alpha-beta T cell activation • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • antibacterial humoral response • positive regulation of T cell mediated cytotoxicity • positive regulation of TRAIL production • positive regulation of interleukin-4 production • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • positive regulation of interleukin-13 production • type I interferon signaling pathway • immune response • regulation of natural killer cell mediated immunity • positive regulation of natural killer cell mediated immunity • regulation of immune response • positive regulation of tumor necrosis factor production • innate immune response • positive regulation of CD8-positive, alpha-beta T cell proliferation • positive regulation of immunoglobulin secretion • antigen processing and presentation of endogenous peptide antigen via MHC class Ib • defense response to Gram-positive bacterium Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3133	15040
Ensembl	n/a	ENSMUSG00000067212
UniProt	P13747	P06339
RefSeq (mRNA)	NM_005516	NM_010398
RefSeq (protein)	NP_005507	NP_034528.1 NP_034528
Location (UCSC)	Chr 6: 30.49 – 30.49 Mb	Chr 17: 36.03 – 36.03 Mb
PubMed search

3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG

3133

15040

n/a

ENSMUSG00000067212

P13747

P06339

NM_005516

NM_010398

NP_005507

NP_034528.1
NP_034528

HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E gene. The human HLA-E is a non-classical MHC class I molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called Qa-1b, officially known as H2-T23.

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