HLA-DRB3

HLA-DRB3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2Q6W, 4H1L
Identifiers
Aliases	HLA-DRB3, HLA-DR3B, DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, major histocompatibility complex, class II, DR beta 3
External IDs	GeneCards: HLA-DRB3
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptide antigen binding • MHC class II receptor activity Cellular component • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endosome • Golgi apparatus • trans-Golgi network membrane • endoplasmic reticulum membrane • membrane • late endosome membrane • Golgi membrane • plasma membrane • transport vesicle membrane • integral component of plasma membrane • MHC class II protein complex • lysosomal membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • lysosome • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane Biological process • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response • T cell receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3125	n/a
Ensembl	n/a	n/a
UniProt	P79483	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	NP_072049	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

2Q6W, 4H1L

3125

n/a

n/a

n/a

P79483

n/a

n/a

n/a

NP_072049

n/a

HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene.

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

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Wikipedia