HLA-DPB1

HLA-DPB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3LQZ, 4P4K, 4P4R, 4P57, 4P5K, 4P5M
Identifiers
Aliases	HLA-DPB1, DPB1, HLA-DP, HLA-DP1B, HLA-DPB, HLA-DPB1, major histocompatibility complex, class II, DP beta 1
External IDs	HomoloGene: 129927 GeneCards: HLA-DPB1
Genetically Related Diseases
hepatitis B
Gene ontology Molecular function • peptide antigen binding Cellular component • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endosome • Golgi apparatus • trans-Golgi network membrane • endoplasmic reticulum membrane • membrane • Golgi membrane • plasma membrane • transport vesicle membrane • MHC class II protein complex • cell surface • lysosomal membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • lysosome • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane Biological process • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • positive regulation of interferon-gamma production • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • positive regulation of T cell activation • positive regulation of T cell proliferation • immune response • T cell receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3115	n/a
Ensembl	n/a	n/a
UniProt	P04440	n/a
RefSeq (mRNA)	NM_002121	n/a
RefSeq (protein)	NP_002112	n/a
Location (UCSC)	Chr 6: 33.08 – 33.09 Mb	n/a
PubMed search		n/a

3LQZ, 4P4K, 4P4R, 4P57, 4P5K, 4P5M

3115

n/a

n/a

n/a

P04440

n/a

NM_002121

n/a

NP_002112

n/a

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

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Wikipedia