HLA-DOB

HLA-DOB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4I0P
Identifiers
Aliases	HLA-DOB, DOB, HLA-DOB, major histocompatibility complex, class II, DO beta
External IDs	MGI: 95925 HomoloGene: 1602 GeneCards: HLA-DOB
Gene ontology Molecular function • MHC class II receptor activity • MHC class II protein complex binding Cellular component • lysosomal membrane • endosome membrane • lysosome • membrane • endosome • integral component of membrane • intracellular • MHC class II protein complex Biological process • negative regulation of antigen processing and presentation of peptide antigen via MHC class II • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • antigen processing and presentation • immune system process • antigen processing and presentation of exogenous peptide antigen via MHC class II • immune response • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3112	15002
Ensembl	n/a	ENSMUSG00000041538
UniProt	P13765	n/a
RefSeq (mRNA)	NM_002120	NM_010389
RefSeq (protein)	NP_002111	n/a
Location (UCSC)	Chr 6: 32.81 – 32.82 Mb	Chr 17: 34.24 – 34.25 Mb
PubMed search

4I0P

3112

15002

n/a

ENSMUSG00000041538

P13765

n/a

NM_002120

NM_010389

NP_002111

n/a

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

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