HLA-DMB

HLA-DMB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1HDM, 2BC4, 4FQX, 4GBX, 4I0P
Identifiers
Aliases	HLA-DMB, D6S221E, RING7, HLA-DMB, major histocompatibility complex, class II, DM beta
External IDs	MGI: 95923 HomoloGene: 68231 GeneCards: HLA-DMB
Gene ontology Molecular function • MHC class II protein complex binding Cellular component • lysosomal membrane • lysosome • membrane • endosome • late endosome membrane • integral component of membrane • MHC class II protein complex Biological process • positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • antigen processing and presentation • MHC class II protein complex assembly • positive regulation of T cell proliferation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • peptide antigen assembly with MHC class II protein complex • immune system process • antigen processing and presentation of exogenous peptide antigen via MHC class II • immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3109	15000
Ensembl	n/a	ENSMUSG00000037548
UniProt	P28068	n/a
RefSeq (mRNA)	NM_002118	NM_010388
RefSeq (protein)	NP_002109	n/a
Location (UCSC)	Chr 6: 32.93 – 32.94 Mb	Chr 17: 34.14 – 34.15 Mb
PubMed search

1HDM, 2BC4, 4FQX, 4GBX, 4I0P

3109

15000

n/a

ENSMUSG00000037548

P28068

n/a

NM_002118

NM_010388

NP_002109

n/a

HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene.

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

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