HLA-DMA

HLA-DMA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HDM, 2BC4, 4FQX, 4GBX
Identifiers
Aliases	HLA-DMA, D6S222E, DMA, HLADM, RING6, HLA-DMA, major histocompatibility complex, class II, DM alpha
External IDs	MGI: 95921 HomoloGene: 4464 GeneCards: HLA-DMA
Gene ontology Molecular function • MHC class II protein complex binding Cellular component • integral component of membrane • cell surface • endosome • lysosome • extracellular exosome • late endosome membrane • membrane • lysosomal membrane • MHC class II protein complex • intracellular membrane-bounded organelle Biological process • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • peptide antigen assembly with MHC class II protein complex • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • immune response • immune system process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3108	14998
Ensembl	n/a	ENSMUSG00000037649
UniProt	P28067	P28078
RefSeq (mRNA)	NM_006120	NM_010386
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 6: 32.95 – 32.97 Mb	Chr 17: 34.14 – 34.14 Mb
PubMed search

1HDM, 2BC4, 4FQX, 4GBX

3108

14998

n/a

ENSMUSG00000037649

P28067

P28078

NM_006120

NM_010386

n/a

n/a

HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

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