HLA-A74

(MHC Class I, A cell surface antigen)

HLA-A74

About

Protein

transmembrane receptor/ligand

Structure

αβ heterodimer

Subunits

HLA-A*74--, β₂-microglobulin

Subtypes

Subtype	allele	Available structures
A74	*7401
{{{cNick2}}}	*74{{{cAllele2}}}
{{{cNick3}}}	*74{{{cAllele3}}}
{{{cNick4}}}	*74{{{cAllele4}}}

Rare alleles

Subtype	allele	Available structures
A74.3	*7403
{{{rnick2}}}	*74{{{rallele2}}}
{{{rnick3}}}	*74{{{rallele3}}}

Alleles link-out to IMGT/HLA database at EBI

Subtype	allele	Available structures
A74	*7401
{{{cNick2}}}	*74{{{cAllele2}}}
{{{cNick3}}}	*74{{{cAllele3}}}
{{{cNick4}}}	*74{{{cAllele4}}}

Subtype	allele	Available structures
A74.3	*7403
{{{rnick2}}}	*74{{{rallele2}}}
{{{rnick3}}}	*74{{{rallele3}}}

HLA A*7401 frequencies

Study population	Freq. (in %)
Colombia African Black	11.6
Kenya	9.4
Cameroon Beti	8.3
Guinea Bissau	7.7
Kenya Luo	7.2
Burkina Faso Mossi	6.6
South African Natal Zulu	6.5
Cape Verde Southeastern I…	5.6
Uganda Kampala	5.2
Cameroon Yaounde	5.0
Cameroon Bamileke	4.5
USA African America	4.0
Cameroon Sawa	3.8
South Africa Tswana	3.7
Mali Bandiagara	3.6
Iran Baloch	2.8
Zimbabwe Harare Shona	2.7
Zambia Lusaka	2.3
Senegal Niokholo Mandenka	2.2
Burkina Faso Rimaibe	2.1
Tunisia Ghannouch	1.8
Kenya Nandi	1.7
Brazil Parana Mulatto	1.6
Brazil	1.5
Morocco Nador Metalsa Cla…	1.4
Thailand Northeast	1.2
Venezuela Colonia Tovar	1.2
Brazil Belo Horizonte	1.1
Thailand	1.1
Tunisia Tunis	1.1
Turkey (1)	1.1

Allele frequencies presented, only

HLA A*7403 frequencies

Study population	Freq. (in %)
Kenya Luo	2.8
Argentina Toba Rosario	0.6
Iran Baloch	0.6
Saudi Arabia Guraiat and …	0.5
Kenya	0.3
Madeira	0.3
Uganda Kampala	0.3

Allele frequencies presented, only

HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁷⁴ subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M . A74 and A*74 are almost synonymous in meaning. A74 is a of the serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.

A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.

A74 has a poor serotyping rate.

A significant association has been found between A74 and nasal polyposis.

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Wikipedia