HIST1H1B

HIST1H1B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2RHI
Identifiers
Aliases	HIST1H1B, H1, H1.5, H1B, H1F5, H1s-3, histone cluster 1, H1b, histone cluster 1 H1 family member b
External IDs	HomoloGene: 136789 GeneCards: HIST1H1B
Gene ontology Molecular function • DNA binding • histone deacetylase binding • chromatin DNA binding • RNA binding • protein binding Cellular component • nuclear heterochromatin • nuclear chromatin • nucleosome • extracellular exosome • chromosome • nucleus Biological process • establishment of protein localization to chromatin • nucleosome assembly • protein stabilization • positive regulation of cell growth • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • positive regulation of histone H3-K9 methylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3009	n/a
Ensembl	ENSG00000184357	n/a
UniProt	P16401	n/a
RefSeq (mRNA)	NM_005322	n/a
RefSeq (protein)	NP_005313	n/a
Location (UCSC)	Chr 6: 27.87 – 27.87 Mb	n/a
PubMed search		n/a

2RHI

3009

n/a

ENSG00000184357

n/a

P16401

n/a

NM_005322

n/a

NP_005313

n/a

Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

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