HIP1

HIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NO2, 2QA7, 3I00
Identifiers
Aliases	HIP1, HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma, huntingtin interacting protein 1
External IDs	MGI: 1099804 HomoloGene: 68463 GeneCards: HIP1
Gene ontology Molecular function • clathrin binding • structural constituent of cytoskeleton • protein binding • phosphatidylinositol binding • actin binding • phospholipid binding • epidermal growth factor receptor binding • phosphatidylinositol-4,5-bisphosphate binding • clathrin light chain binding • phosphatidylinositol-3-phosphate binding • glutamate receptor binding • AP-2 adaptor complex binding • clathrin adaptor activity • protein homodimerization activity • phosphatidylinositol-3,4-bisphosphate binding • protein heterodimerization activity • actin filament binding • phosphatidylinositol-3,5-bisphosphate binding Cellular component • cytoplasm • Golgi apparatus • membrane • intracellular membrane-bounded organelle • clathrin-coated vesicle membrane • cytoskeleton • cytoplasmic vesicle • endomembrane system • clathrin-coated vesicle • nucleus • cytosol • AP-2 adaptor complex • extrinsic component of cytoplasmic side of plasma membrane • extrinsic component of presynaptic membrane • extrinsic component of postsynaptic membrane • presynapse • postsynapse Biological process • regulation of apoptotic process • cell differentiation • positive regulation of receptor-mediated endocytosis • regulation of transcription, DNA-templated • endocytosis • transcription, DNA-templated • clathrin-dependent endocytosis • clathrin coat assembly • apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • apoptotic process • cytoskeleton organization • regulation of endocytosis • positive regulation of epidermal growth factor receptor signaling pathway • protein stabilization • positive regulation of protein kinase B signaling • membrane organization • neurotransmitter receptor transport • positive regulation of platelet-derived growth factor receptor-beta signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3092	215114
Ensembl	ENSG00000127946	ENSMUSG00000039959
UniProt	O00291	Q8VD75
RefSeq (mRNA)	NM_001243198 NM_005338	NM_146001
RefSeq (protein)	NP_001230127 NP_005329	NP_666113
Location (UCSC)	Chr 7: 75.53 – 75.74 Mb	Chr 5: 135.41 – 135.55 Mb
PubMed search

2NO2, 2QA7, 3I00

3092

215114

ENSG00000127946

ENSMUSG00000039959

O00291

Q8VD75

NM_001243198
NM_005338

NM_146001

NP_001230127
NP_005329

NP_666113

Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.

Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a domain homologous to the death effector domains (DED) found on proteins involved in apoptosis. It is believed that accumulation of high levels of the free form of this protein (free as in dissociated from the huntingtin and free to bind other key protein(s)) in the cell is one of the mechanisms by which neuron cell death is caused in Huntington's Disease (via the caspase-3 route). The role of Hip-1 in caspase mediated cell death remains unclear.

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