HIF1A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J

Identifiers

Aliases

HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit

External IDs

MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A

Gene ontology
Molecular function	• protein dimerization activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • transcription factor activity, RNA polymerase II transcription factor binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor binding • enzyme binding • protein binding • histone acetyltransferase binding • protein kinase binding • Hsp90 protein binding • sequence-specific DNA binding • DNA binding • transcription factor activity, transcription factor binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • nuclear hormone receptor binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • ubiquitin protein ligase binding • protein heterodimerization activity • E-box binding
Cellular component	• cytoplasm • cytosol • nucleus • nuclear speck • motile cilium • transcription factor complex • RNA polymerase II transcription factor complex • axon cytoplasm • nucleoplasm • nuclear body
Biological process	• negative regulation of neuron apoptotic process • B-1 B cell homeostasis • regulation of transforming growth factor beta2 production • muscle cell cellular homeostasis • outflow tract morphogenesis • negative regulation of ossification • heart looping • negative regulation of TOR signaling • blood vessel development • hemoglobin biosynthetic process • angiogenesis • positive regulation of chemokine-mediated signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of hormone biosynthetic process • negative regulation of mesenchymal cell apoptotic process • regulation of aerobic respiration • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • lactate metabolic process • regulation of transcription, DNA-templated • blood vessel morphogenesis • positive regulation of erythrocyte differentiation • glucose homeostasis • vascular endothelial growth factor production • regulation of thymocyte apoptotic process • positive regulation of epithelial cell migration • negative regulation of thymocyte apoptotic process • transcription, DNA-templated • positive regulation of transcription, DNA-templated • axonal transport of mitochondrion • positive regulation of macroautophagy • cartilage development • positive regulation of nitric-oxide synthase activity • regulation of transcription from RNA polymerase II promoter in response to hypoxia • lactation • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • digestive tract morphogenesis • cell differentiation • neural fold elevation formation • positive regulation of autophagy • retina vasculature development in camera-type eye • positive regulation of receptor biosynthetic process • collagen metabolic process • embryonic placenta development • negative regulation of apoptotic process • positive regulation of angiogenesis • regulation of glycolytic process • epithelial to mesenchymal transition • cerebral cortex development • regulation of gene expression • positive regulation of chemokine production • intestinal epithelial cell maturation • regulation of catalytic activity • positive regulation of mitophagy • cardiac ventricle morphogenesis • response to muscle activity • epithelial cell differentiation involved in mammary gland alveolus development • visual learning • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of bone mineralization • negative regulation of growth • response to hypoxia • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • iris morphogenesis • mRNA transcription from RNA polymerase II promoter • hypoxia-inducible factor-1alpha signaling pathway • vasculature development • regulation of cell proliferation • neural crest cell migration • embryonic hemopoiesis • connective tissue replacement involved in inflammatory response wound healing • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • elastin metabolic process • positive regulation of glycolytic process • oxygen homeostasis • signal transduction • positive regulation of transcription from RNA polymerase II promoter • cellular iron ion homeostasis • camera-type eye morphogenesis • positive regulation of gene expression • cellular response to hypoxia • cellular response to interleukin-1 • transcription from RNA polymerase II promoter • protein deubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3091


15251

Ensembl


ENSG00000100644


ENSMUSG00000021109

UniProt


Q16665


Q61221

RefSeq (mRNA)


NM_181054 NM_001243084 NM_001530


NM_010431 NM_001313919 NM_001313920

RefSeq (protein)


NP_001230013 NP_001521 NP_851397 NP_001521.1

NP_001300848.1 NP_001300849.1 NP_034561.2 NP_001300848 NP_001300849
NP_034561

Location (UCSC)

Chr 14: 61.7 – 61.75 Mb

Chr 12: 73.9 – 73.95 Mb

PubMed search

1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J

NM_181054
NM_001243084
NM_001530

NM_010431
NM_001313919
NM_001313920

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