HFE gene

HFE

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DE4, 1A6Z

Identifiers

Aliases

HFE, HFE1, HH, HLA-H, MVCD7, TFQTL2, HFE gene, hemochromatosis

External IDs

MGI: 109191 HomoloGene: 88330 GeneCards: HFE

Genetically Related Diseases

cardiovascular system disease, hypertension

Gene ontology
Molecular function	• peptide antigen binding • beta-2-microglobulin binding • co-receptor binding • protein binding • transferrin receptor binding • receptor binding • antigen binding
Cellular component	• integral component of membrane • recycling endosome • HFE-transferrin receptor complex • membrane • basal part of cell • plasma membrane • apical part of cell • integral component of plasma membrane • terminal web • early endosome • MHC class I protein complex • perinuclear region of cytoplasm • cytoplasmic vesicle • external side of plasma membrane • extracellular space
Biological process	• negative regulation of T cell antigen processing and presentation • positive regulation of peptide hormone secretion • positive regulation of receptor-mediated endocytosis • cellular response to iron ion • antigen processing and presentation • negative regulation of receptor binding • regulation of protein localization to cell surface • protein complex assembly • antigen processing and presentation of peptide antigen via MHC class I • female pregnancy • positive regulation of pathway-restricted SMAD protein phosphorylation • response to iron ion starvation • iron ion homeostasis • negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I • ion transport • iron ion import into cell • BMP signaling pathway • cellular response to iron ion starvation • response to iron ion • positive regulation of ferrous iron import into cell • multicellular organismal iron ion homeostasis • positive regulation of ferrous iron binding • positive regulation of transferrin receptor binding • positive regulation of receptor activity • liver regeneration • positive regulation of gene expression • negative regulation of T cell cytokine production • acute-phase response • transport • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of receptor binding • negative regulation of receptor activity • positive regulation of protein binding • hormone biosynthetic process • negative regulation of CD8-positive, alpha-beta T cell activation • cellular iron ion homeostasis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3077


15216

Ensembl


ENSG00000010704


ENSMUSG00000006611

UniProt


Q30201


P70387

RefSeq (mRNA)

NM_000410 NM_001300749 NM_139002 NM_139003 NM_139004
NM_139005 NM_139006 NM_139007 NM_139008 NM_139009 NM_139010 NM_139011


NM_010424 NM_001347493

RefSeq (protein)

NP_000401 NP_001287678 NP_620572 NP_620573 NP_620575
NP_620576 NP_620577 NP_620578 NP_620579 NP_620580


NP_034554.2 NP_001334422 NP_034554

Location (UCSC)

Chr 6: 26.09 – 26.1 Mb

Chr 13: 23.7 – 23.71 Mb

PubMed search

NM_139005
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011

NM_010424
NM_001347493

NP_620576
NP_620577
NP_620578
NP_620579
NP_620580

...
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