HDAC4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S

Identifiers

Aliases

HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4

External IDs

MGI: 3036234 HomoloGene: 55946 GeneCards: HDAC4

Targeted by Drug

tasquinimod, Belinostat, givinostat, panobinostat, quisinostat, romidepsin, trichostatin A

Gene ontology
Molecular function	• NAD-dependent histone deacetylase activity (H3-K14 specific) • sequence-specific DNA binding • DNA binding • core promoter binding • transcription corepressor activity • histone deacetylase activity • protein deacetylase activity • zinc ion binding • transcription factor binding • histone deacetylase binding • potassium ion binding • chromatin binding • activating transcription factor binding • metal ion binding • protein binding • RNA polymerase III transcription factor binding • transcription regulatory region DNA binding • repressing transcription factor binding • protein kinase binding • hydrolase activity
Cellular component	• cytoplasm • histone deacetylase complex • neuromuscular junction • transcriptional repressor complex • sarcomere • nucleoplasm • protein complex • Z disc • A band • actomyosin • nucleus • cytosol
Biological process	• positive regulation of reactive oxygen species biosynthetic process • histone H3 deacetylation • skeletal system development • chromatin remodeling • peptidyl-lysine deacetylation • regulation of cardiac muscle contraction by calcium ion signaling • negative regulation of glycolytic process • response to interleukin-1 • regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • cellular response to tumor necrosis factor • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • positive regulation of protein sumoylation • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of osteoblast differentiation • transcription, DNA-templated • nervous system development • regulation of striated muscle cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of smooth muscle cell migration • B cell activation • histone H4 deacetylation • cellular response to mechanical stimulus • positive regulation of neuron apoptotic process • cardiac muscle hypertrophy in response to stress • positive regulation of cell proliferation • negative regulation of myotube differentiation • response to denervation involved in regulation of muscle adaptation • regulation of skeletal muscle fiber development • osteoblast development • B cell differentiation • cellular response to parathyroid hormone stimulus • inflammatory response • positive regulation of lamellipodium assembly • regulation of protein binding • negative regulation of transcription, DNA-templated • histone deacetylation • response to drug • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • positive regulation of smooth muscle cell proliferation • covalent chromatin modification • chromatin organization • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • protein deacetylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9759


208727

Ensembl


ENSG00000068024


ENSMUSG00000026313

UniProt


P56524


Q6NZM9

RefSeq (mRNA)


NM_006037


NM_207225

RefSeq (protein)


NP_006028


NP_997108.1 NP_997108

Location (UCSC)

Chr 2: 239.05 – 239.4 Mb

Chr 1: 91.93 – 92.2 Mb

PubMed search

2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S

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